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What is AMN?


ADRENOMYELONEUROPATHY (AMN)
Adrenomyeloneuropathy (AMN) is caused by mutations in the ABCD1 gene. This gene is also affected in ALD, a serious degenerative disease that mainly affects young boys. AMN most often appears in adult men. Women can also get AMN, but the condition is usually less severe than in men.

Symptoms of AMN can include stiffness, weakness and pain in the legs. This starts gradually and can progress over time. The medical term for this is ‘progressive spastic paraparesis’. Damage to the nerves supplying the legs means unsteadiness and falls are common. The nerves to the bladder, bowel and sexual organs can also be affected in AMN.

Mobility can gradually deteriorate to the point where the sufferer eventually loses the ability to walk and becomes wheelchair bound. But this does not necessarily happen to all sufferers.

Practical Information for Men with AMN
Practical Information for Women with AMN

Issue Date: March 2015
Review Date: March 2017

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